Currently, reproduction numbers of pandemic models (SIR, SEIR, Lotka-Euler and others), basic or not, and their constituent parameters like transmission rate or duration of infectiousness, mainly are estimated as one average value for either a moving period in time [0,t], or for the whole duration [0,T] of the pandemic. This book statistically investigates these parameters, and thereby the reproduction number as timedependent: hence the name 'Timelocal Reproduction Number'.

For instance, th...